When his most prized possession, a rare collection of Poe poems, is stolen, bookstore owner A. J. Fikry begins isolating himself from his friends, family and associates before receiving a mysterious package that compels him to remake his life.

A miraculous healing serum, kept secret by an ancient puzzle and buried with the mummified remains of Alexander the Great--in a tomb lost to the ages for more than 1,500 years--is the coveted prize for a cunning despot unless Cotton Malone, former U.S. Justice Department agent turned rare-book dealer, can beat her to it.

A mysterious manuscript discovered in the tomb of Charlemagne sends Cotton Malone on a perilous international quest that takes him and twin sisters with their own agenda from an ancient German cathedral to the harsh, unforgiving world of Antarctica in pursuit of the truth about the death of his father on a classified sub mission beneath Antarctica.

"'There are books that are suitable for a million people, others for only a hundred. There are even remedies--I mean books--that were written for one person only...A book is both medic and medicine at once. It makes a diagnosis as well as offering therapy. Putting the right novels to the appropriate ailments: that's how I sell books.' Monsieur Perdu calls himself a literary apothecary. From his floating bookstore in a barge on the Seine, he prescribes...